At an early age, Thuy Vi has demonstrated an interest in singing and performing. While in Vietnam, Thuy has sung and performed in various school productions and events.

In 1975, Thuy Vi and her family left Vietnam and settled in Houston, Texas. During this time, Thuy Vi sang for a local band, performing at various community functions. In 1982, Thuy Vi began singing professionally at a Houston night club.

In 1987, Thuy Vi moved to California and recorded her debut CD, Hot Flash Tonight, with Giang Ngoc productions. It was around this time that Thuy Vi became a household name in the Vietnamese Entertainment circles. She was invited to perform in many states where there are large population of Vietnamese.

Although she is not a lyricist, Thuy Vi has written Vietnamese lyrics for many foreign songs with which she has performed on stage and recorded in many of her albums. Besides dabbling in writing lyrics, Thuy Vi also plays the piano and some guitar.

Thuy Vi's favorite songs are the romantic ballads and songs which speak of unfulfilled love or unfinished love. According to her these unfinished romances are the most beautiful and romantic. Thuy Vi likes Thang Sau Troi Mua and Nhu Da Dau Yeu. Although she says her all time favorite is the latter by Duc Huy, because to her, performing this song leaves the greatest impression on her.

When asked about the audience in San Jose, Thuy Vi said she likes the fans here very much. She thinks they are appreciative of music, and besides, she likes to perform here because she is home.

Currently, Thuy Vi has had much success in video music. She has appeared in many music videos. She has collaborated with Asia Productions and Hollywood Night Productions in these endeavors. She has also worked with many big names in the Vietnamese recording industry. However, her latest CD, Men Tinh Do is the product of her own production company, Thuy Vi Productions. There is also the special appearance of Ma Nu Da Tinh in this album.